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This slow but steady decrease is accelerated by sun exposure, stress, poor diet, smoking, pollution, and lack of sleep

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All aerobic organisms are fundamentally dependent on oxygen, which enables efficient energy production and provokes the oxidative damage of cellular components

Despite the chemical instability of LTA 4 , these processes can be highly efficient and have the potential to increase the concentrations of cysteinyl-leukotrienes at the local level to affect organ function

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In this review, the term chronobiotic is used with conceptual differentiation