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10.1007/s00792-014-0728-8 40 ZhengC.ChenM.WangD.ZhangL.WangJ.ZhangX.et al
A tocopherol and/or actos-controlled clinical trial (NCT05813249) concluded on April 2, 2024, assessing the effects of oral and subcutaneous SEMS on hepatic steatosis and fibrosis improvement in MASLD with T2DM
sitagliptin Sitagliptin Trade Name: Januvia Drug Class: oral hypoglycemics Mechanism of Action: An inhibitor of dipeptidyl peptidase-4 (DPP-4), a protease that degrades the incretin GLP-1 Incretins are hormones released from the GI tract in response to nutrient ingestion Incretins potentiate glucose-stimulated insulin secretion from beta cells in the pancreas As a result of inhibiting DPP-4, increased or prolonged GLP-1 levels are able to potentiate the secretion of insulin by the pancreas The effect produced by DPP-4 inhibitors is dependent on endogenous GLP-1 levels, and produce a modest effect on GLP-1 activity compared to giving GLP-1 receptor agonists (hence DPP-4 inhibitors do not have the same impact to produce weight loss as GLP-1 agonists)
But, quite a few other cell types, can and do, make carnosine, including the kidneys, where the carnosine is nephro-protective
Its just been one surprise after the next, Habener said
When people lose weight rapidly, they usually lose: fat water glycogen AND lean muscle mass GLP-1 drugs are not selective for fat loss
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