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This results in a leaner, more toned physique
In the nucleus, following heterodimer complex formation with transcription factors, like small Maf proteins (G/F/K) and c-Jun, Nrf2 complexes bind to the antioxidant response element (ARE), a regulatory enhancer region within gene promoters that upregulate antioxidant and anti-inflammatory defense processes (Cuadrado et al., 2019
Mouse monoclonal antibody recognizing GST (#2624), and rabbit monoclonal antibodies against hemagglutinin (HA) tag (#3724), calnexin (#2679), cleaved PARP (#5625), AKT pT308 (#13038), and AKT (#4691) were purchased from Cell Signaling Technology
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In the meantime, other well-studied protocols already exist to target these same hallmarks of aging, ranging from pharmacological approaches like rapamycin and SGLT-2 inhibitors to lifestyle strategies such as exercise and caloric restriction
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