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A, Wharton, S., Yokote, K., Zeuthen, N., & Kushner, R
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Hydroxocobalamin is the preferred agent in this patient population (see separate monograph in Less Common Drugs)
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Membrane-bound O-acyltransferase domain-containing 2 (MBOAT2), a ferroptosis inhibitor, operates independently of GPX4 or FSP1 [160]
Furthermore, the KDIGO 2024 guidelines cover combination therapy from the perspective of SGLT2is being first-line therapy, and long-acting GLP-1 RAs being an add-on in adults with CKD and T2D who have not achieved individualised glycaemic targets despite use of metformin and SGLT2is, or who are unable to use those medications [2]
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