Since Tau is a critical microtubule-associated protein stabilising the neuronal cytoskeleton, its depletion indicates severe cytoskeletal destabilisation and axonal degeneration in the diabetic brain [42]
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Methods Ethics statement The Ethics Committee (IRB) of Oilfield General Hospital (Daqing City, Heilong Jiang Province, China) recognizes that this systematic review and meta-analysis of de-identified, publicly available data does not constitute human subjects research as defined by relevant national regulations, and therefore does not require Ethics Committee review
