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In a healthy diet, B12 comes from animal products

De AK, Muthiyan R, Mondal S, Mahanta N, Bhattacharya D, Ponraj P, Muniswamy K, Kundu A, Kundu MS, Sunder J, et al

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Male-stratified analyses showed that men achieved mean weight reductions of 11-13% at 1.0 mg weekly dosing and 14-17% at 2.4 mg weekly, with response rates independent of baseline BMI category

Together they produce a larger, synergistic GH pulse than either alone