Key Takeaways Menopause weight gain is driven by falling estrogen, rising insulin resistance, higher cortisol, and muscle loss, not a lack of effort
Tirzepatide activates both GLP-1 and GIP pathways, while semaglutide primarily activates the GLP-1 pathway
Safe consideration of peptides requires oversight, physician evaluation, and sourcing from regulated compounding pharmacies
Mithoefer et al., 2011)
If Meldonium inhibits fat oxidation and shifts metabolism toward glucose and glycogen breakdown, the resulting increase in glycolytic flux and pyruvate formation will automatically raise lactate production, because lactate dehydrogenase has a very high affinity for pyruvate once its concentration rises, regardless of mitochondrial density or full oxygen availability
Some will take medications less frequently, some may have a lower dose, he says