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20 However, GLP-1RAs have less profound effects on reduction of hospitalisations for heart failure and renal protection than SGLT-2 inhibitors

Substantial evidence has demonstrated that apoptosis, pyroptosis, ferroptosis, and autophagy form an intricate regulatory network, collectively determining the progression of tubular injury through shared signaling pathways and phenotype transition (200, 225, 226) ( Figure 2 )

As we mentioned before, GLP-1R agonism is able to ameliorate neuroinflammation and behavioral deficits induced by hepatectomy or neuropathic pain (63, 64)

Overall Implications for T2D Treatment and Safety Monitoring Overall, GLP-1RAs were associated with improved glycemic control and reduced renal, metabolic, and cardiovascular risks, without elevating cancer risk, supporting their use in individuals with cardiorenal comorbidities

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