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In unstimulated HUVECs, VWF was observed in the endothelial cytoplasm but not on the cells surfaces, whereas in stimulated vessels, long VWF fibers up to 2 mm in length covered the vessel surfaces, binding to platelets predominantly irreversibly

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Genes involved in antioxidant defense and the ubiquitin proteasome system were also upregulated

They also inhibit neural cell necrosis and induce the proliferation of astrocytes

1989 Jan-Feb;10(1):163-70

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