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Second-Line Pharmacological Treatments Antidepressants Targeting Persistent Abdominal Pain Antidepressants are beneficial for IBS patients potentially due to their central effects, but most importantly due to their peripheral effects targeting underlying mechanisms, such as visceral hypersensitivity, pain perception, and motility (Ford et al., 2019)

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Injecting into this thick fat layer causes less pain and less inflammation

At the same time, they may feel more irritable, more reactive, or physically tense without fully understanding why

Implications for diabetes treatment While GLP-1 is typically made in the gut, the study confirms that alpha cells in the pancreas can also release GLP-1into the bloodstream after eating, helping to lower blood sugar by increasing insulin and reducing glucagon levels