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58 Rofecoxib (Vioxx, Merck, Kenilworth, NJ, USA) and Valdecoxib (Bextra, Pfizer, New York, NY, USA) were withdrawn from the market for associated cardiovascular risks and other side effects

GLP- 1 Receptor Agonists in Combination with Insulin The GLP- 1 receptor agonists have been shown to improve blood glucose control when used in conjunction with insulin, particularly basal insulin, and may be particularly useful in the treatment of advanced T2DM [108]

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1123 However, the aforementioned studies were primarily conducted in mouse models, and the clinical outcomes have been consistently unsatisfactory