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Initial colon defect presentation at 4 weeks following fistula creation by anastomosis between the skin and colon defect (c, middle)

Nat Protoc 5:93121

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Therefore, to further dissociate the effects of GSH and NRF2 on lipid abundance and assess if NRF2 activation alone mimics the effects of liver-specific Gclc deletion, we treated Gclc WT mice with CDDO-methyl (CDDO-Me), a form of bardoxolone with increased bioavailability