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Cell 2015;162:44151
doi:10.1210/jendso/bvad016
The GLP-1 receptor effect on gut motility GLP-1 receptor activation is the primary driver of gastrointestinal side effects in retatrutide, just as it is in pure GLP-1 agonists like semaglutide and dual agonists like tirzepatide
However, when patients were then presented with a video detailing the dosing conditions required with oral semaglutide and those with once-weekly injectable dulaglutide, 52.5% indicated a preference for oral semaglutide [90]
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