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No clinical trials on humans have found that raspberry ketones can cause weight loss

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The outcome depends on a few factors, including the severity of the symptoms and the availability of support systems and treatment options

Oxidative stress contributes to the pathology of cancer, cardiovascular diseases, diabetes, neurological disorders (Alzheimers and Parkinsons diseases, Down syndrome), psychiatric diseases (depression, schizophrenia, bipolar disorder), renal disease, lung disease (chronic pulmonary obstruction, lung cancer), and aging

So, unsurprisingly, heavily and forcibly tweaking GLP has unintended side effects and consequences