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IV doses of 25-400 mcg/kg for safety studies Important: These are experimental doses used in animal studies and cannot be extrapolated to other species due to significant differences in metabolism, pharmacokinetics, receptor expression, peptide degradation rates, and tissue distribution patterns

The consequences of NNMT inhibition over months or years are unknown

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3-Adrenergic Receptor Modulation Both hGH and AOD9604 increase 3-adrenergic receptor (3-AR) expression in adipose tissue importantly, restoring repressed 3-AR RNA levels in obese mice to levels comparable with those in lean mice

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