In cohort studies SGLT2 inhibitors were associated with a two-fold increased risk of EDKA as compared with GLP-1RAs
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[16] [18] The addition of glucagon receptor agonism introduces further safety considerations requiring evaluation in Phase 3 trials, including potential effects on heart rate, blood pressure, and hepatic glucose output
Semaglutide and other medications in this class are nutrient-stimulated, hormone-based medications. These medications are working in a way to mimic those hormones that are released from our intestine and our pancreas when we eat, then impact different tissues in our body, she explained
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While this medication offers significant benefits, it's essential to understand the rare but potential risk of pancreatitis, an inflammation of the pancreas that can lead to severe health complications if untreated