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Thus, substantial and mounting evidence supports a direct contributory role of gut microbiota as a participant in CVD pathogenesis, and preclinical studies indicate that the therapeutic targeting of microbial contributors to the TMAO metaorganismal pathway may hold promise as a novel approach for the prevention or treatment of CVD
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Figure 2 shows the timing the occurrence of irAEs [14]
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LeRoith D, Roberts CT Jr
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