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Consider decreasing or closely monitoring the dose of basal insulin to reduce the risk of hypoglycemia
Do not shake your medication or aggressively mix it
Possible side effects of IGF-1 LR3 administration can include [1, 14, 15]: Hyperandrogenism Muscle and joint pain Nausea Headache Impaired glucose metabolism and hypoglycemia Fatigue Changes in sexual function Soft tissue swelling Researchers should thoroughly check glucose, cholesterol, and bone density levels before administering IGF-1 LR3 to test subjects
J.TsapasA.RossingP.MingroneG.MathieuC.et al (2020)
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The standard protocol starts tirzepatide at 2.5 mg regardless of prior semaglutide dose, then escalates every 4 weeks based on tolerance
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