The common side effects of semaglutide are usually mild and may include: Dizziness Headache Tiredness Nausea Vomiting Stomach pain Diarrhea Bloating Constipation Semaglutide can cause rare but serious side effects such as pancreatitis, gallbladder problems, changes in vision, allergic reactions, and kidney issues

Peripheral arterial disease (PAD) is a clinical manifestation of atherosclerotic disease, typically affecting the abdominal aorta, iliac arteries, and lower limbs.1 This condition is associated with a higher risk of major adverse cardiovascular events (MACE) and major adverse limb events (MALE), and is a strong predictor of both all-cause and cardiovascular mortalities.2 Additionally, hospitalizations due to PAD have led to a substantial economic burden on health care systems.3 In addition to their glucose-lowering effects, glucagon-like peptide-1 receptor agonists (GLP-1RAs) are associated with weight loss and have multiple favorable metabolic and anti-inflammatory effects.4 Due to their cardio- and nephro-protective properties, GLP-1RAs are recommended as first-line antidiabetic therapies for patients at high cardiovascular risk.5 Moreover, GLP-1RAs may improve arterial stiffness and provide systemic microcirculatory benefits in the peripheral vascular system

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1 Select confirmatory secondary endpoints included the proportion of participants achieving 10%, 15%, 20% and 25% weight loss, with semaglutide 7.2 mg vs placebo (and for 20% and 25%, semaglutide 7.2 mg vs semaglutide 2.4 mg)
Why It Happens GLP-1 medications affect the digestive system in several ways
Pan T, Wang N, et,al