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Nrf2 is controlled by two distinct -TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity

NeuroReport 7:18331836 Raps SP, Lai JC, Hertz L, Cooper AJ (1989) Glutathione is present in high concentrations in cultured astrocytes but not in cultured neurons

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After that, even bacteriostatic preservation becomes unreliable

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However, these drugs work best when combined with lifestyle changes, including diet and exercise