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Kidney Protection and Brain Health A trial found semaglutide reduced kidney events by 24% in people with type 2 diabetes and chronic kidney disease using a lower dose, not the maximum. GLP-1s also strengthen the blood-brain barrier and enhance neuron survival, with early data hinting at benefits for cognitive decline and Alzheimer's disease. Systemic Anti-Inflammatory Effects GLP-1s reduce systemic inflammation throughout the body. This benefit doesn't get talked about much, though inflammation drives almost every chronic disease
Andrew Huberman has discussed BPC-157 on his podcast as part of broader conversations around peptides and recovery
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Only two of the clinical trials analyzed in the study provided weight data, which showed no difference in weight loss between those with and without PAM variants, but the data is too limited to be conclusive, Gloyn said
Shyer et al., 2020)
NN9535 : a novel long-acting GLP-1 analog recently disclosed, expected to enter phase III (potentially offering daily dosing for weight loss)
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