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The effect was dose-dependent and distinct from PDE5 inhibitors because it works centrally, through hypothalamic MC4R activation rather than peripheral vasodilation (Hadley, 2005)
For all outcomes, we extracted data for the modified intention-to-treat population, defined as all randomly assigned participants who received a least one dose of the study drug
PMID 9367343
More research is needed to conclusively determine their effectiveness
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And then you get that brain fog, that tiredness that sets in, and the last few hours of your work day you might be operating on fumes and maybe a little bit too tired to hit the gym after work, for example
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