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It is recommended to be on semaglutide for over a year as studies showed patients that were on the medication for 5 months regained the weight verses patients that were on the medications for 17 months

American Family Physician

gastrointestinal adverse events (nausea, diarrhea, vomiting) were common but generally mild to moderate

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The most common side effects reported in trials include: Digestive issues Nausea (the most frequently reported side effect) Vomiting Diarrhoea Constipation Stomach pain or discomfort Loss of appetite Other reported effects Fatigue or tiredness Injection site reactions (redness, swelling, or irritation) Most side effects tend to be worse when starting the medication or increasing the dose, and often improve as your body adjusts

Simultaneously, resting metabolic rate drops by 28% per decade after age 30, accelerating during perimenopause and early postmenopause