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In the laboratory study Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo (Chen and colleagues, Proceedings of the National Academy of Sciences, 2007), pharmacologic ascorbate acted as a prodrug that formed hydrogen peroxide in the extracellular space but not in blooda route-dependent effect that oral dosing did not reproduce
Aortic dissection occurs when there is a break in the lining of the artery wall, allowing blood to enter and form a hematoma, further stripping the intima and media of the aorta
PMID: 36372047
-Glutamylcysteine synthetase and active transport of glutathione S-conjugate are responsive to heat shock in K562 erythroid cells
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