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The methylation profile of the tumor was compared with previously defined methylation classes using the publicly available database of the German Center for Cancer Research (DKFZ) (Figure 4A) (Figure 4B) ( Figure 4 Interestingly, the sarcoma classifier showed a match in the primary tumor for soft tissue clear cell sarcoma (Score: 0.96), but EWSR1/CREB1 or ATF1 gene fusion were excluded
In addition, the amount of SCFAs such as butyrate, propionate, isobutyrate, and valerate were decreased, and bile acids such as lithocholic acid were increased in the cecum of the tumour mice [196]
Toxicol Sci 180(2):369382
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