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Knee joint distraction compared with high tibial osteotomy and total knee arthroplasty: two-year clinical, radiographic, and biochemical marker outcomes of two randomized controlled trials

* Correspondence: Fan Guo, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Researchers proposed multiple potential modes of cardiac interaction in these settings, including improving systolic cardiac function, reducing cardiac tissue inflammation, enhancing resistance to oxidative stress, preserving protein quality control, and supporting mitochondrial function in cardiac myocytes in laboratory models