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Research efforts have focused on the regulation of the GLP-1R mediated signaling pathway as a therapeutic approach to type 2 diabetes (T2DM) and have resulted in the development of several FDA-approved GLP-1R agonists

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Future research endeavors should prioritize identifying the variables responsible for heterogeneity in meta-regression analyses, including factors such as gender, drug dosage, and study duration, which can impact changes in HbA1c and weight

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