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in Nature Medicine demonstrated that blocking NNMT in white adipose tissue increased energy expenditure, reduced fat mass, and improved insulin sensitivity in animal models even without changes in diet or activity (Kraus et al., Nature Medicine )

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Compounding advocates countered with some logic that a negative PCAC outcome would have done nothing to protect users who would simply continue purchasing from unregulated vendors

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By blocking NNMT, 5-Amino-1MQ increases NAD+ levels and activates SIRT1, the longevity gene, promoting fat loss, energy production, and metabolic rejuvenation