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Trends in Molecular Medicine

The tiers of evidence are employed in the process of formulating grades of recommendation

Both H 2 O 2 and 3Ac-AP contribute to oxidative stress as a result of polyamine catabolism

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Who Is Typically Included Adults 18 years of age and older BMI of 30 kg/m or higher (obesity), or BMI of 27 kg/m or higher with at least one weight-related condition such as hypertension, dyslipidemia, sleep apnea, or cardiovascular disease No type 2 diabetes (TRIUMPH-1 specifically excluded diabetes