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Several other studies have reported similar direct helminth modulation of non-immune, metabolically active cells (8, 107, 118) ( Table 3 ), predominantly adipocytes and hepatocytes, which communicate with, and influence the function of, -cells

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For type 2 diabetes (NG28), treatment should continue only if there is adequate response (11 mmol/mol [1.0%] HbA1c reduction and 3% weight loss at 6 months)

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These are illustrative concerns, not a contraindication checklist there is no approved indication