Studies have shown many benefits in addition to weight loss- cardiac benefits, slower progression of dementia, lowers asthma, improves fatty liver, helps with knee osteoarthritis and more
Hepatic Safety Hepatic safety has been a particular focus of attention for orforglipron given the hepatotoxicity findings that led to the discontinuation of two competing oral small-molecule GLP-1 programs
However, MCRs are also associated with effects on sexual desire and appetite
Monitor and Adjust Therapy Regular follow-up is essential when starting or adjusting GLP-1 therapy
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A compound called Emideltide, sometimes used for insomnia, was the only one to receive a down vote