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6.2 Potential pathophysiological mechanisms of gut microbiota and metabolite SCFAs in cytokine abnormalities SCFAs (such as acetate, propionate, and butyrate) activate receptors like FFAR2/3 and Gpr109a and inhibit histone deacetylase (HDAC), collectively suppressing the activation of the NF-B signaling pathway, thereby downregulating the expression of pro-inflammatory cytokines (202204)

A forward genetic screen for Arabidopsis mutants with up-regulated GSTF8 promoter activity was conducted by fusing a GSTF8 promoter fragment to the luciferase reporter gene

After filtering the clarified cell lysate through a 0.45 m filter, it was loaded onto the column at a flow rate of 3 ml min 1

doi: 10.1016/j.lfs.2020.118546 199 JinXHeRLiuJWangYLiZJiangBet al

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