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Guideline on Immunogenicity assessment of therapeutic proteins [Internet]

In an accompanying comment, Nauck and Horowitz (2026) highlight that this study should not be interpreted as demonstrating greater efficacy of orforglipron compared to semaglutide, since similar HbA 1c and weight reductions can be achieved with similar adverse event rates with the (not yet licensed in the UK) 25 mg and 50 mg doses of oral semaglutide (Aroda et al, 2023)

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Meanwhile, IL6 can promote migration and invasion by inducing the expression of matrix metalloproteinases (MMPs) and activating epithelial-mesenchymal transformation 35

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