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Absolute contraindications include: Personal or family history of medullary thyroid carcinoma (MTC) Multiple endocrine neoplasia syndrome type 2 (MEN2) Known hypersensitivity to the medication or its components These are based on boxed warnings and prescribing information and should be treated as non-negotiable

35 If you cant compound an oral peptide (which is incredibly difficult), you need to find a way to offer a significant difference for the patients who fail on the pill

They have numerous benefits, but if not monitored, they can lead to significant side effects.

doi: 10.1161/CIRCULATIONAHA.119.041659 68 XieYBoweBXianHLouxTMcGillJBAl-AlyZ