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Overall, tirzepatide reduced the AHI, body weight, hypoxic burden, high-sensitivity C-reactive protein concentration, and systolic blood pressure, and it improved sleep-related patient-reported outcomes

Mol Cell Biochem , 229:7383

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Biopsy-proven NASH : Patients with histologically confirmed NASH, particularly those with significant inflammation or early fibrosis (F1-F2), may be considered for off-label GLP-1 therapy, especially if they have failed lifestyle modification or have contraindications to other therapies like vitamin E or pioglitazone

Chang, B., Nishikawa, M., Nishiguchi, S

However, the remaining fat cells can enlarge if significant weight gain occurs, which may affect the overall contour of the arms