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One 2024 study at the Smell and Taste Center at the University of Pennsylvania (source) found evidence of GLP1 agonists significantly depressing the perception of all five basic taste qualities. Interestingly, while all participants in the study experienced a slight decline in their sense of smell, it was not considered statistically significant suggesting that olfactory changes may be more individualised, or more complex to detect in standardised tests
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A new review suggests that certain combination approaches for obesity pharmacotherapy may be effective when GLP-1 drugs are not
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The trial examined the maintenance of body weight reduction with treatment of orforglipron among participants who previously completed SURMOUNT-5 and received 72 weeks of either tirzepatide (cohort 1) or semaglutide (cohort 2)
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