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While GLP-1RA continue to be successful 17 , combinatorial approaches are being developed due to the hypothesis that additional pathway engagement will generate greater weight loss, durability of weight loss and improved tolerability 7
An MJFF-funded Phase IIb placebo-controlled trial did show mild benefit but because the placebo group also improved, the significance of these results is unclear
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others see subtle improvements
Alexis Cutchins: Once you've figured out where you are so that you don't have post-exertional malaise and you're doing some form of mild cardio exercise every day, then you can start bumping it up by 1 minute at a time
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