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The impact of TXNIP on ferroptosis seems to be manifold, as it downregulates SLC7A11 and GPX4 levels [108,122] , increases the labile iron pool via NCOA4-mediated ferritinophagy [123,124] , and disrupts GSH synthesis (Figure 3) [112]

It is important that dermatologists know about glutathione: its efficacy, the mechanism of hypopigmentary effects, pharmacokinetics, evidence-level and safety profile