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Dimethyl fumarate (DMF) is an approved NRF2 activator that covalently modifies the Keap1 protein (primarily targeting the Cys151 site), thereby blocking the ubiquitination and degradation of NRF2 by the Keap1-Cul3 E3 ubiquitin ligase complex

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Vitamin C (Ascorbic Acid) Helps brighten skin and reduce the appearance of pigmentation

During inner membrane fusion, GTPase activity of OPA1 is modulated and binds to GTP, facilitating conformational changes that enable polymerization and promote inner membrane fusion [77]

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