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What the Research Shows So Far 1

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Download the Executive Summary & Sample Pages of the Type 2 Diabetes Pipeline Report @ #Biotech #Pharma #Type2Diabetes #DiabetesResearch #GLP1 #ClinicalTrials #MarketIntelligence #DelveInsight To view or add a comment, sign in Immunogenicity does not compromise 1-year outcomes with subcutaneous infliximab This post hoc analysis of the LIBERTY-CD and LIBERTY-UC trials provides reassuring evidence that, despite reducing serum drug concentrations, anti-drug antibodies (ADAs) did not significantly impact 1-year efficacy, safety or treatment persistence in patients receiving subcutaneous infliximab maintenance therapy Key findings: Around two-thirds of patients developed ADAs, detected using a highly sensitive drug-tolerant assay ADA-positive patients had lower infliximab concentrations throughout treatment, yet clinical remission, endoscopic outcomes and drug persistence remained comparable to ADA-negative patients Higher ADA titres further reduced drug levels, but still showed no significant effect on 1-year efficacy or safety These findings suggest that therapeutic drug monitoring for subcutaneous infliximab may require approaches beyond serum drug levels alone This study challenges assumptions derived from intravenous infliximab and highlights the need to better understand the relationship between immunogenicity, pharmacokinetics and clinical outcomes with subcutaneous formulations #OpenAccess UEG - United European Gastroenterology #Gastroenterology #IBD #CrohnsDisease #UlcerativeColitis #Infliximab #Biologics #PrecisionMedicine To view or add a comment, sign in Biotech runs on the future tense

Despite the fact that exercise is a potent inductor of the HSP response [89], local and systemic inflammatory lesion leads to a reduction in intracellular HSP70 levels, which may impair tissue readjustment [30, 89, 90]