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Serious adverse effects requiring clinical vigilance include: Lactic acidosis : A rare but potentially fatal complication of metformin, particularly in patients with renal impairment (eGFR 10%), symptomatic hyperglycemia, diagnostic uncertainty, or recurrent hypoglycemia

Clinical outcomes by albuminuria status with dulaglutide versus insulin glargine in participants with diabetes and CKD: AWARD-7 exploratory analysis

Diagnostic procedures

3 Current Pharmaceutical Design (PMC)Sikiric P et al

The LR3 designation refers to the replacement of Glu with Arg at the 3rd position and a 13-amino acid extension at the N-terminus

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