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The Synergy: How They Work Together The most important reason to take both is the Antioxidant Recycling Loop
3,4 Another agent gaining in popularity is tirzepatide (Mounjaro, Zepbound), a dual glucose-dependent insulinotropic polypeptide (GIP)/GLP-1 RA
This may include: Neurological exam to rule out focal deficits Fundoscopic exam to check for papilledema MRI brain with and without contrast if red-flag features present Lumbar puncture with opening pressure measurement if idiopathic intracranial hypertension suspected Discussion of temporary dose reduction or treatment pause Why the headache gets worse during dose escalations The dose-response relationship for GLP-1 headaches is real but modest
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