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Decreased glutathione levels in the TP-overexpressing cells may be in part implicated in the augmented ROS generation in the cells, since glutathione is considered as a main intracellular defense against oxidative stress

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Retatrutide is a triple-receptor agonist targeting GIP, GLP-1, and glucagon receptors

Although phase-2 studies indicated some positive outcomes of ipamorelin for this condition, the benefits observed over 7-10 days were not considered substantial, leading to the discontinuation of clinical development [14, 15]