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Several guidelines currently recommend GLP-1 RAs as add-on therapy to almost all diabetic treatments (with the exception of dipeptidyl peptidase-4 [DPP-4] inhibitors) and even as monotherapy to those intolerant to metformin

Melanotan 2 retains the ability to bind to the melanocortin receptor but with increased affinity and longer duration due to resistance to enzymatic degradation, thus enabling supraphysiological levels of melanogenesis [5]

They had a body mass index (BMI) of at least 30 on the date of treatment initiation or during the latest available primary care visit, or a BMI of at least 27 with one or more weight-related comorbidities such as hypertension, dyslipidemia, obstructive sleep apnea or cardiovascular disease

Although mild, clinicians monitor this effect closely to ensure cardiovascular stability