FIGURE 9 Summary and conclusions: Glutathione and early (premature) inflammaging Chronic inflammatory diseases especially those compromising the lower respiratory system (chronic obstructive pulmonary disease, lower respiratory infections, cystic fibrosis, idiopathic pulmonary fibrosis, acute respiratory distress syndrome), diseases compromising the cardiovascular system (atherosclerosis, ischemic heart disease, stroke, and others), many other systemic inflammatory diseases like diabetes (274, 275)
35,36 They can carry various cargo, including microRNAs (miRNAs), short noncoding RNA, proteins, DNA, messenger RNA (mRNA), nucleic acids and lipids
It also means looking at the full medication list and the patients baseline nutritional and functional status
GLP-1 medications work in several different ways to promote weight loss: 1) by mimicking a naturally occurring GLP-1 hormone in our GI tract, which in turn regulates our insulin and blood sugar levels, 2) by acting in the area of the brain that regulates our hunger cues, and 3) slows stomach emptying which results in feeling fuller for a longer period of time
What exists instead is mechanistic plausibility: tirzepatide drives fat loss at rates faster than most patients have experienced before, and glutathione is the endogenous compound responsible for managing oxidative debris at the cellular level
Because measuring what matters is not only about what we measure but also about understanding why, when and for whom