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Sermorelin, acting on GHRH-R expressed primarily on somatotrophs, is also physiologically selective and does not significantly stimulate cortisol or prolactin at therapeutic doses

TABLE 1 Classification and usage of GLP-1RAs

Future studies employing sophisticated designs, such as ocular-specific GLP-1 R knockout models, are essential to determine if direct neuroprotective effects can occur independently of systemic metabolic correction

Spontaneous hypertension in rats

GLP-1 drugs are used to treat type 2 diabetes and obesity by helping regulate blood sugar levels and reducing appetite

UGT1A1 * 28 polymorphism as a determinant of irinotecan disposition and toxicity