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For M1 polarization, RAW264.7 cells were stimulated with LPS (100 ng mL 1 , Sigma-Aldrich, USA) and IFN- (20 ng mL 1 , ABclonal, China) for 24 h

Theres less collagen and elastin, slower cell turnover, a thinner dermis, and hormonal shifts like lower estrogen that affect your skins barrier and structure

A 2025 human pilot study reported no adverse cardiac, hepatic, or renal effects at IV doses of 10-20mg

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Key takeaways Skin aging results from both internal biological changes and external factors like sun exposure, pollution, and stress, all of which affect how skin looks and behaves over time

This combination helps neutralize free radicals, supports your immune system, and aids in faster recovery from the physical stresses of an active life