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Journal of Translational Internal Medicine, 10 (3), 197206

The immune system adapts to repeated tirzepatide exposure, and the inflammatory response diminishes

US-EQU-0156-2025-V2

Clapp B, Wynn M, Martyn C, Foster C, ODell M, Tyroch A

After injection, it covalently bonds to Cys34 of circulating serum albumin eliminating DPP-IV cleavage and extending half-life from 7 minutes to 5.88.1 days