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Patients with severe deficiency or certain health problems might need a stronger initial treatment

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Among tyrosine kinase inhibitors, imatinib (a PDGFR inhibitor) and erlotinib (an EGFR inhibitor) induce ROS-dependent apoptosis in melanoma and non-small-cell lung cancer cells, respectively, through disruption of mitochondrial membrane potential upon the stimulation of JNK and p38 phosphorylation 88,89 , while vemurafenib (a BRAF inhibitor) increases the production of superoxide anions with the commensurate depolarization of the mitochondrial membranes in melanoma cells 90

Despite this, there are instances where the ability to synthesize GSH, and in turn establish an adaptive response is compromised

Otra de sus funciones es la de proteger el sistema energtico del organismo por su accin de defensa de las mitocondrias, verdaderas centrales productoras de energa celular