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Though the original poster feels like Ozempic has resulted in a net negative after two years, their partner remains intent on staying on the drug and has begun maintenance doses
The semaglutide to tirzepatide conversion chart covers these equivalencies in detail
Study SnapshotStudy TypeSystematic review and meta-analysis, PROSPERO-registered, exploratoryPopulation2,949 adults with multiple sclerosis pooled from 25 studies (49 articles were eligible for review)InterventionNabiximols, a THC/CBD oromucosal spray already approved as add-on therapy for MS spasticityComparatorPlacebo or standard care across the pooled randomized and non-randomized studiesPrimary Outcomes AssessedBladder function, sleep disruption, spasm quality, and gait/timed walkSecondary OutcomeSubject Global Impression of Change (SGIC) at one monthDatabases SearchedWeb of Science, MEDLINE via PubMed, Cochrane CENTRAL, and Embase, searched September 10, 2025Main FindingSignificant improvement in spasm quality, bladder function, sleep disruption, and timed walk
Laboratory studies report that GHK-Cu can modulate the synthesis of collagen, elastin, and glycosaminoglycans while influencing matrix metalloproteinase and TIMP activity
Novo immediately threatened to sue, and then the FDA said that it plans to take decisive steps to limit access to the active ingredients in popular GLP-1 drugs like Wegovy, Ozempic and Zepbound
doi: 10.2139/ssrn.4653984 132 SanzABSanchez-NinoMDRamosAMOrtizA
